Immunology [Paperback]

A brief, clear overview of the basic science and clinical aspects of immunology. For medical students and other health professionals

PART I. BASIC IMMUNOLOGY

CHAPTER 1. THE WORLD OF THE IMMUNE SYSTEM

-- Innate Immunity (Natural Killer Cells; Complement pathways)

-- Adaptive Immunity (Humoral immunity; Antibodies; Molecular features of immunoglobulins; Cell-mediated immunity)

CHAPTER 2. LYMPHOCYTES AND ANTIGENS

-- Antigen Recognition

-- Major Histocompatibility Complex (MHC)

-- MHC Polymorphism

-- T Cells and Antigen-presenting Cell Interaction

-- Antibody Production (Activation of B Cells; Interaction of B cells and T helper cells; Isotope switching)

CHAPTER 3. OTHER IMPORTANT COMPONENTS OF THE IMMUNE SYSTEM

-- Eosinophils

-- Basophils

-- Mast Cells

-- Cytokines (Classification of cytokines; Cytokines and disease)

PART II. CLINICAL IMMUNOLOGY

CHAPTER 4. HYPERSENSITIVITY

-- Type I Hypersenstitivity Reaction (IgE-mediated) (Allergic rhinitis)

-- Type II Hypersensitivity Reaction (Antibody-mediated) (Blood transfusion reaction)

-- Type III Hypersensitivity Reaction (Immune complex-mediated) (Serum sickness)

-- Type IV Hypersensitivity Reaction (Cell-mediated; Delayed type) (Mantoux reaction; Allergic contact dermatitis)

-- Eosinophils and Disease (Eosinophilia)

-- Mast Cells and Disease (Mastocytosis)

CHAPTER 5. AUTOIMMUNITY

-- Central Tolerance: T Cells

-- Peripheral Tolerance: T Cells

-- Central and Peripheral Tolerance: B Cells

-- Factors Predisposing to Autoimmunity

-- Mechanisms of Autoimmunity

-- Autoimmune Diseases (Diagnosis of autoimmune diseases; Hashimoto thyroiditis; Systemic lupus erythematosus; Rheumatoid arthritis; Sjogren syndrome; Scleroderma)

CHAPTER 6. COMMON DIAGNOSTIC TESTS

-- In Vivo Testing (Prick skin testing; Intradermal testing; Provocative in vivo tests; Patch tests)

-- In Vitro Testing (ELISA; Radioallergosorbent test; Western blotting; Precipitation; Agglutination; Direct and indirect immunofluorescence)

CHAPTER 7. IMMUNODEFICIENCY

-- Primary Immunodeficiency (Immunodeficiency affecting adaptive immunity; Immunodeficiency affecting humoral immunity; X-linked agammaglobulinemia; Common variable immunodeficiency; IgA deficiency; Hyper immunoglobulin E syndrome; T cell deficiency; DiGeorge syndrome; Combined B and T cell deficiency; Ataxia telangiectasia)

-- Secondary (Acquired) Immunodeficiency

-- Diagnosis of Immunodeficiency (Workup for primary immunodeficiencies of the innate immune system; Workup for primary immunodeficiences of the adaptive immune system)

-- Management of Immunodeficiency (Management of AIDS)

CHAPTER 8. VACCINATION

-- Immune Response to Vaccination

-- Types of Vaccines

-- Characteristics of an Ideal Vaccine

-- Recommended Vaccines for Children and Adults (including Pneumococcal vaccine; Human papillomavirus vaccine; Shingles vaccine)

-- Passive Immunotherapy (Primary immunodeficiency and the use of IVIG)

CHAPTER 9. TRANSPLANTATION

-- Types of Grafts

-- Graft Success

-- Graft Rejection

-- Graft-Versus-Host Disease

-- Current Practices in Organ Transplantation

CHAPTER 10. TUMOR IMMUNOLOGY

-- Classification of Malignant Tumors (Carcinogenesis)

-- Risk and Predisposing Factors of Malignancies

-- Immune Response to Tumors (Immune surveillance and immunoediting; Elimination; Equilibrium, Escape)

-- Tumor Immunotherapy (Active immunotherapy; Passive immunotherapy)

Index